Serologic and Dermal Reactions in Guinea Pigs Injected Intradermally with Brucella Antigens

[摘要] 1. 1. Dermal sensitivity was not induced in guinea pigs by repeated intradermal injections of brucellergen, brucellin, or a Brucella vaccine containing 200,000,000 dead cells per ml.2. 2. Repeated intraperitoneal injections of guinea pigs with brucellergen or brucellin failed to stimulate a significant production of either agglutinins or complement fixing antibodies. Brucella vaccine, however, prepared from dead cells was antigenic when administered intraperitoneally and caused significant antibody formation.3. 3. The quantity of each agent required to cause production of serum antibody is many fold the amount used in successive intradermal tests. The order of increasing antigenicity of the Brucella preparations tested was: brucellergen, brucellin, and Brucella vaccine.4. 4. The data obtained from guinea pigs indicate that repeated intradermal tests with brucellergen will not sensitize patients to protein nucleates derived from Brucella .

[学科分类] 生物科学（综合）