Cytopathogenicity and Propagation of Variola Virus in Tissue Culture

[摘要] Variola virus has been shown to induce cytologic changes and to propagate in a variety of human and animal cell strains derived from both normal and malignant tissue. One exception occurred in which the L cell strain was agglutinated by large virus quantities. The cytologic changes and agglutination were prevented by specific immune serum. A linear logarithmic relationship existed between the quantity of virus used and the quantity of serum required to neutralize the virus in a tissue culture neutralization test.

[学科分类] 生物科学（综合）