Passive Cutaneous Anaphylaxis in the Mouse

[摘要] The skin of the albino Swiss mouse can be passively sensitized by rabbit antibody. With the rabbit antihen egg albumin used in this study, 0.4 or 0.8 μg antibody nitrogen was found to be the lower limit necessary for local sensitization. The optimal latent period was found to be 3 hr. Intradermally injected antibody can be detected by PCA for only a short time after challenge with antigen. When the antibody is injected intravenously, 350 μg of antibody nitrogen or more are necessary to sensitize the skin. At these antibody levels the threshold amount of Ea approximated 0.25 μg.

[学科分类] 生物科学（综合）