Concerning the Cytopathogenic Effect of Poliovirus; Evidence for an Extraviral Toxin

[摘要] A toxic effect of fluids obtained from tissue cultures infected with type 1 poliovirus was observed when the fluids were introduced into fresh cultures. The destructive activity is distinct from the usual virus-induced cytopathogenic effect in that it occurs rapidly, without a prolonged latent period and without virus production. The infectious activity can be selectively neutralized by antiserum with full retention of the toxicity. However, certain antisera will also neutralize the toxin. Further, the two activities possess differential heat stability. The ability to destroy cells and give rise to detectable amounts of toxin is a characteristic of only certain lines of the poliovirus.

[学科分类] 生物科学（综合）