The Immune Response of the Guinea Pig to the Antigens of Pasteurella Pestis

[摘要] In experimental antiplague immunization the reaction of the guinea pig has been unique. Of greatest interest have been the difficulties in immunizing this animal either with aqueous suspensions of killed plague bacilli or with antigenic extracts of Pasteurella pestis , both highly immunogenic in the mouse, rat and monkey. The report that follows is an account of the development of the present conclusions about the immune response of this animal.Materials and Methods. Strains of P. pestis . 1) Yreka, a virulent strain originally isolated from a fatal human infection in Yreka, California. 2) 195/P, a virulent strain from the Haffkine Institute in Bombay, India. It was originally isolated from a fatal pneumonic plague infection, and a sample of the culture was lyophilized and shipped to the Hooper Foundation. 3) Shasta, a virulent strain isolated from a fatal bubonic infection in 1951. 4) 111, a virulent strain isolated from a fatal pneumonic infection in Madagascar.

[学科分类] 生物科学（综合）