Typhoid Agglutinin Production: The Rôle Dosage, Total Amount of Agglutinogen Injected and Frequency of Inoculation Play

[摘要] Frequency of injections plays a major rôle in typhoid agglutinin production.A close relationship exists between the interval of injections and the dose employed.Total amounts of agglutinogen injected have but little direct influence, however some indirect influences are apparent.The axiom of frequent stimulation of the body cells of the animal by the use of small doses of agglutinogen and by larger doses as the intervals between inoculations are increased, is emphasized.Typhoid agglutinins with greatest potencies are produced by injecting 0.1 cc. frequently; 1 cc. less frequently and 5 cc. still less often.Typhoid agglutinins with high titers are possible with any of the three doses studied; the highest, however, follow the employment of the largest dose.Typhoid agglutinins of equal potencies are elaborated irrespective of dosage, when inoculations are made every third day.Increasing the dose with each subsequent injection results in agglutinins with much higher titers than when the reverse is true.Non-specific agglutinin formation is negligible.Physical deterioration of the rabbits shows its effect on. agglutinin production.Comparable results are obtained with various agglutinogens, precipitinogens and lysinogens.

[学科分类] 生物科学（综合）