Analysis of the Anaphylactic and Immune Reactions by Means of the Isolated Guinea-Pig Lungs

[摘要] Analyses of the anaphylactic and immune reactions by means of perfusion experiments with the isolated guinea-pig lungs show that we are here concerned with three essential factors: 1. ( a ) Cellular hypersensitiveness , or the anaphylactic response of the hypersensitive fixed pulmonary tissues,2. ( b ) Humoral anaphylaxis , or the chemical response (anaphylotoxin formation) of the anaphylactic blood, and3. ( c ) Humoral immunity , or the inhibiting or protecting action of the immune blood.In the 14-day anaphylactic guinea-pig, the fatal bronchial spasm is due, in part to fixed cellular hypersensitiveness, in part to humoral anaphylaxis.In the 4-week anaphylactic guinea-pig, the fixed cellular hypersensitiveness is usually greater than that of the 14-day anaphylactic guinea-pig. The humoral reaction, however, is usually absent. The fatal bronchial spasm in the 4-week anaphylactic guinea-pig is usually due solely to fixed cellular hypersensitiveness.The immune guinea-pig usually shows a fixed cellular hypersensitiveness greater than that of the 14-day anaphylactic guinea pig. A fatal bronchial spasm is prevented in the immune guinea-pig, however, by the inhibiting or protecting action of the immune blood.The immune guinea-pig, therefore, shows a seemingly paradoxical phenomenon, the coexistence of a fixed cellular hypersensitiveness and a humoral immunity.

[学科分类] 生物科学（综合）