Multiplication of Coxsackie Virus in Adult Mice Exposed to Roentgen Radiation

[摘要] Swiss white mice weighing 10 to 12 g were exposed to whole body roentgen radiation 24 to 120 hours before the intraperitoneal inoculation of the Powers strain of Coxsackie virus. Nonirradiated control mice were injected with virus at the same time. At regular intervals thereafter mice from each group were sacrificed and the viral content of selected organs determined.In general, virus could be demonstrated over a longer period of time in the organs of the irradiated mice as compared to the controls, and with rare exceptions the former yielded a consistently higher viral titer. When the amount of X-radiation was varied higher concentrations of virus were demonstrated in the organs of mice receiving greater exposure. In contrast to these findings the increase in mortality rates among the irradiated mice was irregular and at best moderate. Irradiation of mice 48 hours after inoculation of the virus was not followed by a demonstrable increase in either virus yield or mortality rate as compared to non-irradiated control animals.

[学科分类] 生物科学（综合）