The Specificity of Precipitins for Serum

[摘要] 1. 1. It has been verified that a single series of injections of small quantities (2 to 3 cc.) of undiluted serum-protein into rabbits will yield an antiserum that will give “group” reactions but seldom “extra-group” reactions.2. 2. Such antisera do not give settled precipitates under the conditions described and the flocculative titer is lower than the interfacial titer.3. 3. Reinjection of such rabbits with minute quantities of a 2 per cent homologous antigen results in an antiserum but slightly different from the initial antiserum produced.4. 4. The titer of the rabbit's blood falls considerably within a 2 months' period after the first injection-series or reinjections with dilute solutions.5. 5. Reinjections with undiluted serum result in antisera whose reactions ( a ) are aspecific, ( b ) give much settled precipitation, ( c ) react more quickly than those resulting from one injectionseries or reinjection of 2 per cent solutions, ( d ) reach a maximal titer (after one hour) usually after 2 injection-series, which thereafter cannot be increased by further injections.

[学科分类] 生物科学（综合）