The Effect of Heterologous Bacterial Products Upon Tuberculous Animals

[摘要] It has long been known that tuberculous animals respond with focal and systemic reactions to injurious agents not related to tubercle bacilli. In human beings non-specific focal and systemic reactions can be observed when tuberculosis is associated with certain infectious diseases, when tuberculous patients are injected with foreign proteins (heterotherapy) or metal salts. Mollgard and others (1) observed severe systemic and focal reactions after the injection of a gold salt (sanocrysin) in tuberculous man and animals. Lewis, Menkin and others (2) found that dyes and metal salts accumulate in tubercles in larger amounts than in normal tissues. Dienes (3) reported that in tuberculous guinea pigs that had been sensitized to egg white a very small amount of this protein produces hemorrhages in tissues containing tubercles and “tuberculin” death.Observations by Sanarelli (4) on rabbits infected with cholera vibrios afforded a new approach to the problem of the specificity of focal and systemic reactions.

[学科分类] 生物科学（综合）