The Rôle of Clasmatocytes in the Resistance of Rabbits to Infection with Pasteurella Lepiseptica

[摘要] 1. 1. Mononuclear (clasmatocyte) accumulations, obtained by seventy-two hour pleural cavity preparation with aleuronat and starch, were definitely correlated with enhanced resistance of rabbits to intrapleural infection with Pasteurella lepiseptica .2. 2. Polymorphonuclear accumulations, obtained by eighteen hour preparation of the pleural cavity with the same irritant, had slight effect on enhancing the resistance of rabbits to intrapleural infection with Pasteurella lepiseptica .3. 3. Specific immune serum injected intrapleurally into normal rabbits together with an infecting dose of Pasteurella lepiseptica had a definite protective effect, but was not as effective as local mononuclear accumulations. Normal serum so applied appeared to be without protective effect.4. 4. The passive intrapleural transfer of seventy-two hour pleural exudate, either alone or followed by immune serum given intravenously, failed to protect normal rabbits against approximately one hundred fatal doses of Pasteurella lepiseptica administered simultaneously.5. 5. Following the intravenous injection of specific immune serum, in quantities alone unable to protect, the intrapleural administration of cell-suspensions from seventy-two hour exudates (clasmatocyte type) was superior to cell-suspensions from twenty-four hour exudates (polymorphonuclear type) in protecting normal rabbits against approximately one hundred fatal doses of Pasteurella lepiseptica given simultaneously.

[学科分类] 生物科学（综合）