Passive Sensitization of Human Skin by Serum of Experimentally Sensitized Animals

[摘要] In studying the relationship between the spontaneous sensitivity or allergy of man and experimental anaphylaxis in animals, the possibility of passive transfer of sensitivity between the various species is of considerable interest. In their study of the Prausnitz-Küstner (1) passive-transfer reaction, Coca and Grove (2) injected serum of experimentally sensitized animals into human skin, attempting to produce a passive local sensitization comparable to that produced by serum of allergic humans. They used anti-egg and anti-ragweed rabbit serums, both of which contained specific precipitins. Neither passively sensitized human skin. Coca (3) considered this a distinction between anaphylaxis and allergy.Cooke and Spain (4) injected six anti-egg rabbit serums, all of which contained precipitins and readily passively sensitized guinea pigs, into the skin of several human subjects. Three of the serums produced specific passive local sensitivity on test with egg-white, three did not.

[学科分类] 生物科学（综合）