Studies on the Chemical Nature of Shwartzman-Active Substances

[摘要] 1. 1. Shwartzman-active substances are contained in two different chemical fractions of bacterial substances.2. 2. The so-called “nucleoprotein” fraction is always found to be Shwartzman-active; it is derived from bacterial autolysis or extraction. Its potency is increased in alkaline solution.3. 3. Most of the potency of agar-washings is connected with an alcohol-precipitable biuret-negative fraction. The appearance of these Shwartzman-active substances does not depend on autolytic processes, but is metabolic in character.4. 4. The Shwartzman-active substances of the last described fraction are highly unstable, precipitable with small volumes of alcohol and not identical with type-specific carbohydrates.5. 5. The Shwartzman-active factor of filtered washings is slowly dialyzable and resists trypsin digestion.

[学科分类] 生物科学（综合）