Studies on the Toxicity of Human Blood Plasma for Guinea-Pigs

[摘要] Blood plasma obtained from pregnant women is more toxic for the guinea-pig on intravenous injection than plasma obtained from normal individuals. Human placental plasma is practically nontoxic. Similar relations are found with dog plasma obtained from pregnant dogs and from full term fetuses.Plasma obtained during the menstrual cycle (before and after) is occasionally more toxic for guinea-pigs than normal female plasma.The cause of death in the guinea-pig is an intravascular clotting of the capillaries of the lungs, with a resulting asphyxia, and occlusion in other capillaries as well (brain, liver, etc.). Death can be prevented if the animal is hirudinized, or if the amount of citrate simultaneously injected, is increased.

[学科分类] 生物科学（综合）