Studies on the Toxicity of Human Blood Plasma for Guinea-Pigs

[摘要] I. Introduction. In our previous report (1), we have briefly mentioned the phenomena produced by the intravenous injection of human plasma into the guinea-pig which we associated with coagulation changes. It is the object of this paper to report in some detail the results of this observation, and to show briefly the relationship it has with anaphylaxis and the associated phenomena.The theories of anaphylaxis and anaphylactic shock are so numerous that it is only possible to mention a few of them, especially those which may have any bearing on our findings. Biedl and Kraus (2), Schultz and Jordan (3) among others have shown that the peculiar and rapid fatal character of anaphylactic shock in the guinea-pig depends on the valve-like closure of the bronchioles, due partly to the special susceptibility of the bronchiolar musculature, and partly to the thick lining of these tubes in the guinea-pig, so that when contraction of the bronchi take place, the lumen is obstructed.

[学科分类] 生物科学（综合）