The Alteration of Bacterial Endotoxins by Human and Rabbit Serum

[摘要] Incubation of Salmonella typhosa endotoxin in normal human and rabbit serum was found to alter the precipitating activity of the endotoxin. By quantitative techniques, it was demonstrated that the extent of alteration is a function of time and temperature of incubation, pH and concentration of serum and endotoxin. The serum factor appeared to be relatively stable at 56°C. Evidence was presented that eliminated the properdin system as responsible for the alteration. The characteristics of this reaction are discussed.

[学科分类] 生物科学（综合）