Effect of Preradiation Immunization on Resistance to Aerosol-Induced Infection in X-Irradiated Mice

[摘要] Immunization with Klebsiella pneumoniae prior to x-irradiation increased the resistance of mice to challenge with an aerosol of the living organisms. This protective effect of preradiation immunization was not destroyed at sublethal to near midlethal levels of exposure (levels at which mortality resulting from overwhelming infections are implicated as an important cause of death). The results presented show that a large total irradiation dose, given in increments, is far less detrimental to the host defenses than the same dose acutely administered.

[学科分类] 生物科学（综合）