Studies on the Chemotherapy of Viral Infections

[摘要] A study has been made of the effect of caprochlorone on influenza virus infection in the de-embryonated egg. The compound is not virucidal nor does it affect the adsorption of influenza virus on susceptible cells (35). A true virustatic action of the compound has been revealed. When treatment was given early in the growth cycle, maximal inhibition was produced by 2 mg per egg. Dosage above this level did not increase the extent of inhibition. When treatment was administered later in the growth cycle of the virus, increased inhibition was obtained as exposure to the compound was prolonged. With the maximal dose of the compound that is nontoxic to the chorio-allantoic membrane a small amount of viral reproduction can still occur. Washing the cavities of de-embryonated eggs with glucosol during exchange of fluids or reducing the residual virus level by RDE treatment in the early stage after de-embryonation did not alter this result. Caprochlorone was active on the intracellular phase of the influenza virus in both the early and late stages of the growth cycle. A more pronounced inhibition was found on hemagglutinin formation and on the infective form of the virus than on soluble antigen formation. The reversibility of the suppressive effect was shown by treatment of the infected membranes with the compound for short periods of time.

[学科分类] 生物科学（综合）