Studies on the Chemotherapy of Viral Infections

[摘要] The effect of caprochlorone on influenza virus infection in mice has been studied. The titers of virus in the lungs of the treated mice were on the average 10-fold lower than that found in the lungs of the control group. The efficacy of such treatment, however, decreased when the infectious dose was greater than 10 MLD50.The possibility of a combined therapy using both caprochlorone and antiserum was investigated. Human γ globulin was used as the source of antiserum. A definite synergistic effect was demonstrated with the combined therapy in that mice infected with 3000 MLD50 were saved, whereas infections with 3 and 30 MLD50 were prevented by caprochlorone alone and γ globulin alone, respectively. It has been shown also that mice infected with the virus 3 days previously were cured by the combined therapy. The significance of this is discussed.

[学科分类] 生物科学（综合）