Corneal Reactions to Horse Serum in Rabbits Passively Sensitized by Leukocytes

[摘要] Sensitization of experimental animals to serum antigens commonly results in the formation of circulating antibody. Subsequent reactions of the skin to the antigen are predominantly of the immediate type of sensitivity. These reactions are quantitatively related to the level of circulating antibody; they can be elicited in normal animals after passive sensitization with antigserum. However, occasional “delayed” or tuberculin-like reactions of the skin to serum antigens have been reported in actively sensitized animals (1) and in man (2). The number and intensity of “delayed” responses is increased when animals are sensitized with antigen plus acid-fast bacilli: injection of antigen into an active tuberculous lesion (3), incorporation of antigen with killed tubercle bacilli in oil (4), and use of extracted “wax” from tubercle bacilli as an adjuvant (5) are all effective techniques. Reactions of the skin to antigen after these procedures have characteristics of both immediate- and delayed-type sensitivity reactions.

[学科分类] 生物科学（综合）