Poliomyelitis Vaccine Safety Testing by the Tissue Culture Method

[摘要] Details are given of the method of tissue culture safety testing of inactivated poliomyelitis virus strain pools and the subsequent trivalent vaccine, as developed and utilized in the production of a formaldehyde-ultraviolet irradiation inactivated vaccine. Data obtained, using formaldehyde as the sole inactivating agent, are compared with those obtained utilizing the combination (formalin-ultraviolet) method. Certain fundamental and theoretical aspects of inactivation rate data accumulated over the past few years are discussed.

[学科分类] 生物科学（综合）