Pasteurella Pestis Antibody Patterns in Sera of Plague-Convalescent and Vaccinated Persons Determined by Immunoelectrophoresis and Passive Hemagglutination

[摘要] The relative immunogenicity of different Pasteurella pestis vaccines and antigens and the influence of different inoculation schedules have been studied extensively on rodents and primates.In general, immunity against fatal infection by P. pestis has been correlated with antibodies in the peripheral blood, measurable in vivo by the passive mouse protection test (1). In vitro demonstrable antibodies against the Fraction I (F1) or envelope antigen likewise reflect immunity. Rodents (2) inoculated with different vaccines or primates (3, 4) in the 3rd month of recovery from infection with complement fixation (CF), and high passive hemagglutination (HA) titers and mouse protective indices (MPI) below 5, survive subcutaneous or pulmonary challenge with virulent organisms. Complete resistance against infection is usually indicated when the serum protects nearly all the mice in the protection tests. Although the presence of particular antibodies in rodents and primates indicates a state of immunity to infection, it has been argued that they may or may not be protective.

[学科分类] 生物科学（综合）