A New Serum Factor in Normal Rabbits

[摘要] The sera of 36 normal rabbits reacted specifically with the univalent 3.5 S fragments produced by papain digestion of rabbit γG-globulin. The reaction was demonstrated by the agglutination of human red cells sensitized by the univalent fragments of rabbit antihuman erythrocyte antibody. The activity of the serum factor was inhibited by the 3.5 S univalent fragments of normal rabbit γ-globulin.The data suggest that the reactive factor, herein termed “homoreactant,” is one of a number of serologically distinct anti-γ-globulin factors. The factor was shown to reside in the 7 S γ-globulin fraction of serum, to be nondialyzable, and heat- and mercaptoethanol-resistant.The data further suggest that papain digestion of rabbit γ-globulin reveals a buried antigenic groups; this group may be related to the genetically determined antigenic groups of rabbit γ-globulin (allotypes).Differences between homoreactant and other serum factors are discussed.

[学科分类] 生物科学（综合）