Adoptive Tolerance to Shigella Antigen in Irradiated Mice Receiving Spleen Cell Transplants from Unresponsive Donors
[摘要] 1. 1. Spleen cell suspensions from young mice immunologically tolerant to Shigella paradysenteriae antigens, induced by neonatal injection of a large inoculum of the antigen, were not competent to form agglutinins when transferred to lethally x-irradiated recipient mice.2. 2. Challenge injection of irradiated recipients with Shigella antigen at various time intervals following spleen cell transfer from Shigellatolerant donor mice did not result in normal levels of agglutinins, as occurred following transfer of spleen cells from normal or Shigella-immune donors.3. 3. Irradiated mice receiving unresponsive spleen cells were capable of forming normal levels of antibody to sheep erythrocytes or bovine serum albumin.4. 4. Adoptive tolerance could not be demonstrated with any degree of confidence in non-irradiated recipients capable of actively forming antibody to Shigella antigens, either with or without spleen cell transfer from normal, Shigella tolerant or Shigella immune donors.
[发布日期] [发布机构]
[效力级别] [学科分类] 生物科学(综合)
[关键词] [时效性]