Delayed Hypersensitivity in Vitro

[摘要] 1. 1. The migration of peritoneal exudate cells from guinea pigs with delayed hypersensitivity to tuberculin purified protein derivative, ovalbumin and diphtheria toxoid is markedly inhibited by the respective antigen, and such inhibition is specific.2. 2. Cells from guinea pigs producing precipitating antibody are not inhibited by antigen.3. 3. Sera from experimental animals exhibiting delayed hypersensitivity or sera containing precipitating antibody did not sensitize normal cells to antigen.4. 4. The inhibition still occurs when heat-in-activated sera are used.5. 5. The findings are consistent with the view of the primary importance of cells in manifestations of delayed hypersensitivity reactions, and the in vitro system gives promise of further elucidation of the mechanism involved.

[学科分类] 生物科学（综合）