Decreased Immunogenicity of a Transplantation Antigen in Hosts Sensitized to Other Isoantigens of its Cellular Vehicle

[摘要] 1. 1. Accelerated rejection of male skin isografts by C57BL/6 female mice occurs as a consequence of previous injection of 20 million male CBA spleen cells by either the i.p. or i.v. route.2. 2. However, if the test mice are immunized against CBA isoantigens from female donors 20 days before inoculation of the male CBA cells, rejection of the test grafts is significantly delayed.3. 3. The inhibitory effect of prior CBA isoimmunization on sensitization to the male factor does not occur when isologous male cells are mixed with CBA female spleen cells and inoculated.4. 4. These results are interpreted as evidence that the secondary response to the CBA isoantigens is capable of blocking access of the male antigen to those sites in which the primary response can be initiated.

[学科分类] 生物科学（综合）