γ-Globulin and Antibody Formation In Vitro

[摘要] The effect of whole body irradiation, administered on days 8 or 21 after a primary intravenous injection of BGG, on the ability to respond to a subsequent booster injection given at various intervals was studied in rabbits. It was found that late irradiation was followed by a permanent partial inhibition of the booster response, whereas early irradiation resulted in inhibition followed by a rapid recovery during the following week. This recovery was correlated with the destruction and reappearance of secondary nodules in the white pulp of the spleen. The cellular aspects of the various parameters of the irradiation effects are discussed.

[学科分类] 生物科学（综合）