Studies of Antipneumococcal Serum

[摘要] These studies of type-1 antipneumococcal rabbit sera collected during periods of immunization and rest showed that there was a roughly corresponding quantitative change in complement-fixing capacity and combining activity with type-1 carbohydrate antigen.In general, during the period of immunization, the complement-fixation titer rose progressively to a maximum as judged both by the amount of complement fixed and by the quantity of antigen needed for maximum fixation by given amounts of serum; it fell rapidly after injections were discontinued but rose again abruptly to a maximum on resumption of immunization, in some instances beyond the earlier maximum.Irrespective of whether the titer was very low or very high, linear relationships were observed between serum and complement and between serum and antigen. Throughout, the ratio of antigen to serum giving maximum fixation closely approximated “equivalence” proportions.

[学科分类] 生物科学（综合）