Intradermal Spread of Vital Dye in Anaphylaxis and Bacterial Allergy

[摘要] The ability of sensitized tissue to retain or fix a specific antigen locally, is a well known phenomenon. Thus Opie (1) has shown that rabbits sensitized with crystalline egg albumin or horse serum, localize these antigens at the point of injection in the skin, without the antigen entering the circulation. Kahn (2) has likewise shown that rabbits sensitized with diphtheria (horse) antitoxin, retain the antigen locally long before any manifestation of anaphylaxis can be demonstrated.Animals rendered allergic with bacteria possess the same ability to retain the antigen locally. The best example of this fact is offered in experimental tuberculosis. Thus Krause and Willis (3) have shown that if excised lymph-nodes draining the site of inoculation with tubercle bacilli in the normal animal are injected into other normal guinea pigs, it can be demonstrated that the tubercle bacilli reach these lymph-nodes within twenty-four hours.

[学科分类] 生物科学（综合）