Potency-Determination of Antipertussis Serum by the Mouse-Protective Test

[摘要] Reproducible results may be obtained by the procedure given for conducting the mouse-protective test with antipertussis serum.This has made it possible to establish a provisional standard unit for use in the evaluation of antipertussis rabbit-serum by the mouse-protective test.A provisional standard unit is defined as that amount of standard serum which will protect 50 per cent of the mice against 2 MLD of a virulent strain of H. pertussis suspended in 4 per cent gastric mucin.Antipertussis rabbit-sera may be standardized in terms of a control serum using White's formula.This method of conducting the mouse-protective test in the potency-determination of antipertussis sera is practical and assays specific protection in terms of provisional units.

[学科分类] 生物科学（综合）