Some Suggestive Experiments with B. Influenzae; Its Toxin and Antitoxin

[摘要] Susceptibility of Laboratory Animals. The question as to the pathogenicity of Pfeiffer's bacillus for laboratory animals has never been given the attention it deserves, as practically all text books dismiss the subject with a very few words, leaving an impression that it is non-pathogenic, except for the human subject and perhaps the monkey.Woolstein has called attention to the pathogenicity of this organism for the monkey, rabbit, guinea-pig and white mouse. She found that the white mouse “succumbs to intraperitoneal injections of cultures irrespective of their origin” giving rise to a peritoneal exudate containing large numbers of the influenza bacilli, as does the heart's blood. The microorganisms were found in other organs, and the spleen was always swollen.Guinea-pigs succumb to intraperitoneal injections of one blood agar culture of all meningeal, and about one-half of the respiratory strains tested. The peritoneal fluid was increased at times to 8 cc. and the spleen was increased to two or three times its normal size.

[学科分类] 生物科学（综合）