Studies in Protein Intoxication

[摘要] It has long been known that the parenteral injection of albumoses or “pepton” into animals produces marked effects on blood pressure and on the coagulability of the blood. The earliest important work was reported by Schmidt-Muelheim in 1880 (1) and by Fano in 1881 (2). The similarity of this “pepton poisoning” to anaphylactic shock was noted by de Waele in 1907 (3), by Biedl and Kraus in 1909 (4), and by Arthus (5). Since these original observations were recorded an enormous amount of study has been devoted to this topic with the purpose of analysing the mechanism of this toxic action, and possibly of throwing some light on the mechanism of anaphylaxis. Hardly any observations, however, have been recorded on the histologic changes resulting from pepton poisoning.Simonds (6) describes marked passive hyperemia occurring in the livers of dogs dying from acute pepton shock, and thrombi in the sinusoids of the livers after several injections of peptone.

[学科分类] 生物科学（综合）