Studies on the Chemotherapy of Vaccinia Virus

[摘要] A series of thiosemicarbazones were studied for antivaccinial activity in chick embryos and in mice. Of those studied, benzaldehyde, 3-thiosemicarbazone, its p-acetamido, p -amino, p -methoxy, p -propoxy and p -ethylsulfonyl analogs were the most effective against vaccinia in chick embryos.In mice infected intranasally with vaccinia, benzaldehyde, 3-thiosemicarbazone, its p -acetamido analog and the N4 isobutyl derivatives of these two compounds were the most effective, but only at doses near the maximal tolerated dose administered in the diet two days prior to infection and for ten days after infection.

[学科分类] 生物科学（综合）