On the Stability of Desiccated Snake Venoms
[摘要] The toxic potencies of desiccated snake venoms were tested over a period of up to 13 years.It was found that the non-hemorrhagic, so-called neurotoxic venoms had lost little or nothing of their original toxicity in 8 to 9 years of storage in cork stoppered glass tubes in the dark. Hemorrhagic venoms kept under the same conditions had lost 41 to 56% of their power in 9 years and 84% in 13 years ( Vipera ) and 78 ( Bitis ) and only 14 ( Agkistrodon )% in 8 years. When stored in a frequently opened and re-evacuated desiccator, Agkistrodon venoms lost approximately 70% of activity within one year. Under similar conditions, lyophilized neurotoxic Crotalus venom lost about one third of its original toxic potency in a couple of months whereas its antibody-binding capacity decreased less markedly, if at all.The significance of these observations is discussed.
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[效力级别] [学科分类] 生物科学(综合)
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