Complement-Fixing Antibodies of Lymphogranuloma Venereum in Mice: Their Development and Response to Sulfonamide Therapy

[摘要] A study has been made of the development of complement-fixing antibodies in mice following infection with the virus of lymphogranuloma venereum. Antibody usually could be detected at 1 week and was always demonstrable at the end of 2 weeks after inoculation. A peak in titer was reached 3 to 5 weeks after infection. A high titer persisted throughout the 18-week period of observation. Virus could be recovered from the brains of the animals at any time after the appearance of signs of illness and throughout the period of recovery.A remarkable correlation was found to exist between antibody-titer and the timing and duration of sulfonamide therapy. Animals treated from the time of inoculation for a period of several weeks gave negative tests for antibodies at the end of this time. In mice treated after the infection had been established, titers of antibody were lower than in control animals, and a definite relationship was found between the end-titer and the duration of therapy. When therapy was continued for several weeks, the antibodies disappeared completely. Virus could still be recovered from the tissues of these animals, but the ease with which it was isolated depended upon the program of chemotherapy.

[学科分类] 生物科学（综合）