Specific Aggregation of Streptococcal Proteins Adsorbed on Oil Droplets

[摘要] A bacterial antigenic preparation in solution may possess several specificities, some of which become apparent only under special conditions.Adsorption of a group-specific protein (NPA) derived from streptococci Lancefield Group A, on olive oil changes the reactivity in an agglutination reaction from predominantly group-specific to predominantly type-specific.When this protein is adsorbed on olive oil globules, it behaves serologically more like intact streptococci than when it is in solution, in that it shows a prozone in the region of antibody excess and exhibits cross-reactivity in low dilutions of antisera.Adsorption of NPA on a non-streptococcal bacterial surface did not change the specificity of the protein from that exhibited by NPA in solution.It is suggested that the type-specific activity of NPA complex may be due to the hapten “T”.

[学科分类] 生物科学（综合）