The Effect of Fumaropimaric Acid on Delayed Hypersensitivity and Cutaneous Forssman Reactions in the Guinea Pig

[摘要] Fumaropimaric acid, when injected into guinea pigs by the intraperitoneal route, is effective in suppressing the cutaneous reaction to intradermally administered hemolysin (Forssman reaction) and the cutaneous contact reaction to a skin-sensitizing compound, o -chlorobenzoylchloride (delayed hypersensitivity). Guinea pigs did not respond to fumaropimaric acid in a parallel manner with respect to these two kinds of reactions, suggesting that the mechanism of inhibition was different for each. Although a suggestive relationship between degree of anticoagulation and delayed hypersensitivity response was observed in these experiments, there was no correlation between anticoagulation and reactivity to the hemolysin. Similarly, a conventional anticoagulant, heparin, had no demonstrable effect on the Forssman reaction. These results support previous studies which relate the anti-Forssman activity of fumaropimaric acid entirely to its ability to interfere with the complement system. It is suggested that the effect of fumaropimaric acid on delayed hypersensitivity reactions may be due to its ability to inhibit an underlying chemical reaction which is related to some stage of the clotting sequence.

[学科分类] 生物科学（综合）