Subgroup-Specific Antigenic Marker on Immunoglobulin λ Chains: Identification of Three Subtypes of the Variable Region

[摘要] Three distinct classes of human k light polypeptide chains have been detected immuuochemically (1). The three antigenic types correspond to the three basic variable sequences designated as k i, k ii and k iii (2). In previous reports (3, 4) we described two specificity region subgroups of human λ chains tentatively called (St+) and (St-), differing in antigenic determinants localized on the variable (V) or NH2- terminal region of the λ molecule.In the course of studies on the delineation of the (St-) subgroup with various antisera, several rabbit antisera were encountered which showed differences among (St-) type Bence Jones proreins and λ chains of myeloma proteins in immunodiffusion analysis. Similar differences were found for the (St-) type proteins of normal serum. The antigens involved correlate with certain structures of the V region of the λ polypeptide chain.Myeloma proteins and Bence Jones proteins were isolated and typed with respect to subgroup (4).

[学科分类] 生物科学（综合）