Appendix and γM-Antibody Formation

[摘要] Intravenous injection of 200 µg of alum-precipitated bovine γ globulin into irradiated (900 r) rabbits, whose appendix and bone marrow had been shielded during irradiation, gave rise to an early hemagglutinin response predominantly of the γM immunoglobulin type. This effect was exaggerated by direct injection of antigen into the appendiceal artery or into the lumen of the appendix. Infection by either route of antigen freed of aggregated material by centrifugation gave little immune response and appeared to inhibit formation of γM antibody on subsequent challenge with alum-precipitated antigen. Late formation of γG antibody and the development of memory (ability to give an early γG response after secondary challenge) were not affected by irradiation of the appendix, but were inhibited in animals whose bone marrow was not shielded during irradiation.

[学科分类] 生物科学（综合）