The Relative Susceptibility of Normal and X-Rayed Mice of Different Stocks to Pneumotropic Viruses

[摘要] Different inbred stocks of mice varied in susceptibility to intranasal infections with influenza-B and other pneumotropic viruses. Of the four stocks tested, the black agouti mice (lC3H and C3H) proved significantly more susceptible than the three albino stocks (Swiss, Ak and Rf). Both morbidity and mortality were higher among the black agouti than among the albino mice.Stock C3H carries the “milk-factor”, a virus-like agent responsible for the high incidence of mammary carcinoma in this stock. However, a genetically identical line, namely lC3H, which is free from this milk-factor, proved equally susceptible to the pneumotropic viruses.Total irradiation with 300 r given 24 to 48 hours before intranasal infection significantly increased the susceptibility of the mice of all the stocks to small infecting doses of pneumotropic viruses.

[学科分类] 生物科学（综合）