The Rôle of Pathogenicity-Enhancing Substances in Mice Infected with Shigella Dysenteriae (Shiga) and other Enterobacteriaceae

[摘要] 1. 1. Two mucin preparations of different origin showed different degrees of effectiveness in enhancing the pathogenicity of intraabdominally injected S. dysenteriae .2. 2. Fractionation of these mucins showed that the active mucin (N) contained more of an insoluble fraction rich in inorganic substance, mostly aluminum, than did the less effective preparation W.3. 3. Kaolin, as well as other inert adsorbing powders, activates some carbohydrates. Agar showed a weak pathogenicity-enhancing effect, but was activated by kaolin and other adsorbing powders. Levan itself, as well as carbohydrate fractions (M1) from mucin, showed marked effects, which were enhanced by kaolin. Glycogen and starch were inactive and were not activated by kaolin.4. 4. The activity of the pathogenicity-enhancing substances was inversely proportional to the rapidity of their elimination from the abdominal cavity. Kaolin and other adsorbing substances retard elimination.5. 5. Injection of bacteria with kaolin or with agar preceded or followed by an injection of an adsorbent had the same effect as a combined injection of the two substances.6. 6. The following properties are important for the effect of pathogenicity-enhancing substances: long persistence in the abdominal cavity, ability to adsorb and destroy white cells and, as a consequence, to prevent phagocytosis. The effect is, therefore, not an enhancement of pathogenicity but a depression of the mechanism of natural resistance.

[学科分类] 生物科学（综合）