The Complementary Activity of Mouse-Serum

[摘要] The serum of the mouse differs from that of most animals in that it is without complementary activity. Its serum fails to hemolyze sensitized sheep-cells. Ritz in 1911 (1) observed that mouse-serum contains one component of complement called the midpiece but that the endpiece is missing. This phenomenon is analogous to that given by the fresh serum from a strain of complement-deficient guinea-pigs first reported by Moore (2). A thorough study of this serum by Coca (3), Ecker (4) and Hyde (5, 6) has shown that it is activated in a hemolytic system by very small amounts of heated serum from man or the normal guinea-pig. Thus, the midpiece and endpiece of complement are normally present in this serum but the third complement-component, the heat-resistant or yeast-absorbed component, is missing.The separation by various methods of guinea-pig complement into several components has been described by Leifmann (7, 8), Browning and Mackie (9) and Whitehead, Gordon, and Wormall (10, 11).

[学科分类] 生物科学（综合）