Histamine-Protein Complexes: Synthesis and Immunologic Investigation

[摘要] 1. 1. A synthetic antigen was prepared by coupling the isocyanate derivative of histamine with despeciated horse serum globulin.2. 2. The immunologic properties of the antigen were studied. The antiserum gave cross-reactions with histamine-azo-proteins, and the precipitative reaction was inhibited by histamine and by β-(5-Imidazolyl) ethyl isocyanate.3. 3. Protection against symptoms of anaphylaxis in guinea-pigs after immunization with the complex was demonstrated by both in vivo and in vitro experiments.

[学科分类] 生物科学（综合）