On the Differences in Activity of Serum Complement from Various Animal Species

[摘要] 1. 1. The normal sera of ox, rabbit, and sheep were found to be highly bactericidal for Brucella suis , while normal guinea pig serum showed no such activity. The bactericidal activity of the above sera was destroyed by heating at 56.5°C. for 30 minutes or by absorption with heat-killed Brucella suis .2. 2. Guinea pig complement would not activate the normal thermostable antibody of ox, rabbit, or sheep serum against Br. suis . Rabbit complement activated only heated rabbit serum. Ox complement activated almost completely the killing power of heated sera of the rabbit and ox, and only partly that of the heated sheep serum. Sheep complement restored completely the bactericidal power of heated normal sheep and rabbit sera, and activated heated ox serum nearly to the same degree as did ox complement.3. 3. The order of these complements arranged according to their ability to activate certain normal bactericidins is just the opposite to a similar arrangement for complements in hemolytic systems.4. 4. Our data show that complements vary in their ability to activate normal bactericidins against Brucella suis , and therefore the complements from different animal sources are not always interchangeable in normal bactericidal reactions.

[学科分类] 生物科学（综合）