Tissue Localization of Two Populations of Human Lymphocytes Distinguished by Membrane Receptors

[摘要] Lymphocyte suspensions from man and primates show a high proportion of cells adhering to sheep erythrocytes (E) forming rosettes (1–3). The binding of E to lymphocytes is dependent on temperature and is probably not immunologic in nature because 20 to 40% of normal human peripheral blood lymphocytes form rosettes when incubated with E (1). It appears as if the lymphocytes which have receptors for E constitute a subpopulation of lymphoid cells which are thymus dependent or derived (T) since almost 100% of human thymocytes form this type of rosette (1).A number of reports validate the use of certain membrane markers for the characterization of lymphocyte populations. Distinct markers for “T” and bone marrow-derived (“B”) type cells have been described on the membrane of mouse lymphocytes: the theta (θ) alloantigen (4–6), the receptors for a modified complement component (C3) (7–9) and the membrane-bound immunoglobulins (8, 10, 11).

[学科分类] 生物科学（综合）