Genetic Control of Immune Response to Glutamic Acid, Alanine, Tyrosine Copolymers in Mice

[摘要] The immune responsiveness of 21 inbred and congenic strains of mice to two copolymers of L-glutamic acid, L-alanine and L-tyrosine, GAT10 and GAT4, was investigated. Mice of the H-2a, H-2b, H-2d and H-2k histocompatibility alleles were responders to GAT10, whereas strains possessing the H-2f, H-2j, H-2p, H-2q, H-2r, H-2s and H-2w histocompatibility alleles were nonresponders, indicating an association between immune responsiveness and the H-2 locus. Although the response to GAT4 was also linked to H-2 locus as above, the P strain having the H-2p allele produced a minimal response. The study of the specificity of the antibody produced with the cross-reacting polymers GA(T2) and GT indicated that the recognition of the antigenic determinant is under separate genetic control.

[学科分类] 生物科学（综合）