A Genetic Polymorphism of Peromyscus 7Sγ1 Globulins: Detection by Differences in Electrophoretic Mobility

[摘要] A genetic polymorphism for electrophoretic variants of the 7Sγ1 globulin in the deer mouse, Peromyscus maniculatus artemisiae , was demonstrated. The electrophoretic mobility of the 7Sγ1 globulin (or its Fc piece) in an individual serum represented one of three phenotypes—a relatively homogeneous fast or slow migration or a heterogeneous fast-slow mobility. All three phenotypes were detected in male and female mice from laboratory-reared and wild populations. Results of breeding experiments indicated that the electrophoretic variants were the result of two codominant alleles of the 7Sγ1 H chain gene. The unusual expression of 7Sγ1 allotype by electrophoretic variants in both Peromyscus and Mus musculus suggests that this mutational event occurred in a common ancestor.

[学科分类] 生物科学（综合）