The Effect of Antiplasma Cell Sera on the Primary Immune Response

[摘要] An antiserum, antiplasma cell sera (APS), prepared against mouse myeloma cells was specifically cytotoxic to myeloma cells; the cytotoxicity could be absorbed out only with myeloma cells. When tested in a hemolytic plaque assay, APS greatly reduced the number of direct (IgM) plaque-forming cells (PFC) when administered 1, 2 or 3 days after immunization with sheep red blood cells (SRBC). The APS was also effective in vitro in reducing the number of direct PFC in spleen cell suspensions from mice that had been immunized 4 days earlier with SRBC. As determined in a skin allografting model, APS had no obvious effects on cellular immunity.

[学科分类] 生物科学（综合）