The Secondary Response to High and Low Dose Priming in Mice

[摘要] Although the level of the antibody response to an antigen is generally considered to be proportional to the antigen dose over a wide dosage range, this is not necessarily true for the secondary response. Sterzl (1) found that neonatal rabbits and piglets primed with a suboptimal dose of sheep red blood cells (SRBC) gave a higher direct and indirect plaque-forming cell (PFC) response to a second antigen injection than did animals that were immunized with a dose optimal for a maximum primary response. Recently, Hanna and Peters (2) reported similar results in adult mice immunized with SRBC. In the primary response, spleens from mice immunized with 2 × 108 SRBC contained approximately twice as many direct PFC and 20 to 30 times as many indirect PFC as mice primed with 2 × 106 SRBC.

[学科分类] 生物科学（综合）