Tissue Culture Studies of Venezuelan Equine Encephalomyelitis Virus

[摘要] VEE virus, classified as a neurotropic agent, will survive and multiply in human uterine tissue fragments.The virus has been carried through 15 subcultures in human uterine tissue and has retained its pathogenicity for mice by intracerebral inoculation. This represents a total dilution factor of the original virus of at least 10−43.Tissue culture flasks as here used are not as sensitive an indicator of virus infectivity as is the intracerebrally inoculated mouse.The tissue fragments in such cultures contain considerably more virus than the supernatant fluids.

[学科分类] 生物科学（综合）